Abstract
Typhoid fever is one of the major health problems in Bangladesh. It is caused by the bacterium Salmonella enterica serovar Typhi (S. Typhi). S. Typhi is a highly virulent host restricted invasive pathogen that affects only humans. It remains an important cause of enteric disease in children in developing countries. It is estimated that more than 33 million cases of typhoid fever occur annually causing more than 500,000 deaths. Salmonella organism are extensively distributed in nature and causing widespread of disease in men and animals. Salmonella enterica serovar typhi causes typhoid fever, which is classically characterized by fever, headache, rose-colored rash, abdominal pains, diarrhea, paradoxical bradycardia and various other symptoms. This article discuses and summarizes important work in the literature in response to the epidemiology of typhoid fever, Salmonella related to international trade and use of animal model to study typhoid. In this communication, we also reviewed the pathogenesis of Salmonella organism, immune response of typhoid fever and its prevention. Vaccination in relation to typhoid fever has been also focused. This review will let the reader to have a retrospective study on typhoid in concerned with Salmonella.
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