Abstract
Objective To compare the efficacy of venlafaxine combination of cognitive behavior therapy or lithium or olanzapine for treatment-resistant depression. Method A prospective stratified randomized controlled clinical trial were adopted to the patients with treatment-resistant depression. 69 cases were divided into three groups with random number table, each group including 23 cases. One group was with venlafaxine combination of cognitive behavior therapy, others with combination of lithium, or olanzapine, for 6 weeks to observe the efficacy. The major indexes for therapeutic effects was Hamilton Depression Scale (HAMD) reducing score rate. Results The differences were significant in HAMD reducing score rate between the group with combination of cognitive behavior therapy[(61±5) %] and the group with combination of lithium [( 54 ± 7 ) %] ( t = 8.90, P < 0. 05 ), or olanzapine [( 47 ± 6 ) %] ( t =3.46,P < 0.05 ), with no significant difference is between the group with combination of lithium and the group with combination of olanzapine. Conclusion The total efficacy of venlafaxine combination of cognitive behavior therapy is superior to venlafaxine combination of lithium or olanzapine for treatmet-resistant depression. Key words: Depressive disorder; Cognitive therapy; Behavior therapy; Verdafaxine
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