Abstract
A quinaldine functionalized probe QP has been designed and synthesized. It exhibited selective turn-off fluorescence response toward Cu2+ ion over most of the biologically important ions at physiological pH. The binding ratio of the probe QP and Cu2+ ion was determined to be 1:1 through fluorescence titration, Job's plot and ESI-MS. The binding constant (K) of Cu2+ to probe QP was found to be 2.12×104M−1. Further, the Cu2+ ensemble of probe QP was found to respond H2PO4− and HPO42− among other important biological anions via fluorescence turn-on response at physiological pH. Fluorescence microscopy imaging using living Hela cells showed that probe QP could be used as an effective fluorescent probe for detecting Cu2+ cation and H2PO4− and HPO42− anions in living cells.
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