Abstract
AbstractA wide variety of chemicals having distinct odors are smelled by humans. Odor perception initiates in the nose, where it is detected by a large family of olfactory receptors (ORs). Based on divergence of evolutionary model, a sequence of human ORs database has been proposed by D. Lancet et al (2000, 2006). It is quite impossible to infer whether a given sequence of nucleotides is a human OR or not, without any biological experimental validation. In our perspective, a proper quantitative understanding of these ORs is required to justify or nullify whether a given sequence is a human OR or not. In this paper, all human OR sequences have been quantified, and a set of clusters have been made using the quantitative results based on two different metrics. Using this proposed quantitative model, one can easily make probable justification or deterministic nullification whether a given sequence of nucleotides is a probable human OR homologue or not, without seeking any biological experiment. Of course a further biological experiment is essential to validate the probable human OR homologue.
Highlights
IntroductionThe outcomes of Human Genome Project (HGP) have allowed researchers to begin to understand the blueprint of genes and genomes
1.1 Current State of Art and Authors' contributionThe Human Genome Project (HGP) was an international research effort, coordinated by the National Institutes of Health and the U.S Department of Energy to determine the sequence of the human genome and identify the genes that it contains [1, 2, 3 and 4]
Let us elaborate in detail, the result obtained for all human Olfactory Receptors (ORs) using the above stated methods
Summary
The outcomes of HGP have allowed researchers to begin to understand the blueprint of genes and genomes. Discovering the sequence of the human genome was only the first step in understanding how the instructions coded in DNA lead to a functioning human being. The stage of genomic research will begin to derive meaningful knowledge from the DNA sequence. Gene therapy is an experimental technique that uses genes to treat or prevent disease. This method of therapy would allow us to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery.
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