Abstract
Ganglioside GM1 (GM1) micelles have been studied by means of water proton T1 NMRD experiment. The field dependent spin-lattice relaxation rates were measured for Larmor frequencies ranging from 0.1 ...
Highlights
GM1 ganglioside are amphiphilic molecules with a hydrophobic part consisting of a sphingosine and a fatty acid
We may study the information content of the water proton T1-NMRD profiles obtained from fast field cycling (FFC)-NMR dispersion experiments
The hydration on the other hand is not well known and The reorientation of the spherical ganglioside micelles here the proton water R1-NMRD experiment provide some new information about the hydration of the micellar head group
Summary
GM1 ganglioside are amphiphilic molecules with a hydrophobic part consisting of a sphingosine and a fatty acid. The bulky hydrophilic part is built up by several sugar units. This system is rather well studied and is comprised of large spherical micelles with a stable aggregation number of ≈ 168 ± 4 in the temperature interval T¡ 30oC [1]. We may study the information content of the water proton T1-NMRD profiles obtained from fast field cycling (FFC)-NMR dispersion experiments. Water 1H longitudinal relaxation rates, R1exp(ω) of figure 1, was measured on a 1T Stelar FFC2000 fast-field-cycling instrument with polarization at 25 MHz and detection at 16.29 MHz. Relaxation takes place at different proton Larmor frequencies ranging from 0.01 to 40 MHz. The switching time is 3 ms, with a 90o pulse length of 7.8 μs.
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