Abstract
A Protein Complex Restrains a Homicidal Enzyme during Sperm Differentiation
Highlights
If one were to take a moral view of cell activities, the caspases would be condemned on two counts
What restrains the lethal machinations of caspases to allow selective degradation of subcellular components is not clear, though there is evidence that inhibitory proteins may prevent caspase activation at inappropriate times
The assumption is that each complementation group contains a different mutation responsible for the defect—thereby revealing the different genes required for the normal condition
Summary
If one were to take a moral view of cell activities, the caspases would be condemned on two counts. Eli Arama et al provide support for this scenario by showing that an enzyme complex activates caspases by degrading their inhibitors during Drosophila sperm differentiation. The Drosophila IAP (called Diap1) thwarts apoptosis by degrading an initiator caspase; Diap1 is inactive, in cells destined to die.
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