Abstract
Objective To evaluate the effects of whole brain radiotherapy (WBRT) on cognitive function and quality of life (QOL) in patients with brain metastases from lung cancer. Methods A total of 41 patients with brain metastases from lung cancer who were admitted to our hospital and treated with WBRT in 2015 were enrolled as subjects. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used for cognitive evaluation. The Alzheimer′s Disease Cooperative Study Activity of Daily Living (ADCS-ADL) scale was used for evaluation of QOL. Comparison of cognitive function and QOL before and after WBRT was made by the independent sample t-test. Results The incidence rates of cognitive dysfunction based on MoCA and MMSE were 96.55% and 48.28% before WBRT, and 94.29% and 31.43% after WBRT, respectively. There were no significant changes in MoCA score, MMSE score, or ADCS-ADL score after WBRT (18.24±0.95 vs. 19.37±0.70, P=0.341; 23.51±0.88 vs. 24.54±0.71, P=0.375; 57.44±2.59 vs. 59.37±2.27, P=0.583). Conclusions WBRT has no significant impacts on cognitive function and QOL in patients with brain metastases from lung cancer. MoCA is more sensitive than MMSE in detection of cognitive dysfunction in patients with brain metastases. Key words: Brain metastases, lung neoplasms/whole brain radiotherapy; Cognitive function; Quality of life; Scale
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