Abstract
A prospective randomized double blind study to compare the effects of dexmedetomidine and fentanyl on intubating conditions during awake fiberoptic bronchoscopy guided intubation - IJCA- Print ISSN No: - 2394-4781 Online ISSN No:- 2394-4994 Article DOI No:- 10.18231/2394-4994.2018.0078, Indian Journal of Clinical Anaes
Highlights
IntroductionFlexible fiberoptic guided endotracheal intubation in awake patients is the mainstay of anticipated difficult airway management where conventional laryngoscopy becomes difficult due to either inadequate mouth opening or inability to extend the neck
Various drugs have been used for sedation to provide adequate intubating conditions during awake fiberoptic intubation (AFOI) but these drugs may cause excessive sedation followed by respiratory depression which is undesirable in these patients.So this study was planned with aim to compare dexmedetomidine with fentanyl for conscious sedation during AFOI in adult patients posted for various elective surgical procedures under general anaesthesia
Group A (n=30); Dexmedetomidine dexmedetomidine 1.5 μg/kg diluted in 100 ml normal saline over a period of 10 min while Group B (n=30); Fentanyl Group received IV fentanyl 2 μg/kg diluted in 100 ml normal saline over a period of 10 min
Summary
Flexible fiberoptic guided endotracheal intubation in awake patients is the mainstay of anticipated difficult airway management where conventional laryngoscopy becomes difficult due to either inadequate mouth opening or inability to extend the neck. Dexmedetomidine, a selective α-2 adrenoceptor agonist, provides conscious sedation and analgesia with minimal respiratory depression It facilitates decrease in salivary secretions with anxiolytic and amnesic properties along with maintaining stable haemodynamics, which are desirable properties of a drug for AFOI and makes it an ideal and suitable drug to be used for this procedure.[3,4,5,6,7,8,9,10] Fentanyl, a strong agonist at the μ-opioid receptor, is a synthetic opioid analgesic (75 to 125 times more potent than morphine) with a rapid onset and short duration of action. In this prospective randomized study, we planned to compare IV dexmedetomidine (1.5 μg/kg) with IV fentanyl (2 μg/kg) for conscious sedation during AFOI in patients posted for various elective surgical procedures under general anaesthesia
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