A Prospective Observational Study on Assessment and Evaluation of Cephalosporin in General Medicine Department at Tertiary Care Hospital

Abstract

BACKGROUND: The main of the study is to determine the Rational use of cephalosporins in general medicine. The key objectives to analyze the drug safety and utilization in prescription and to study the indications for which drug is prescribed. Methods: A total of 150 patients enrolled in the study from general medicine department in tertiary care hospital. The documented data were evaluated for use of safety outcomes for the treatment associated with the use of cephalosporins. The data’s were collected using specially designed data entry form and appropriateness is assessed with the help of NICE guidelines. Results: Cephalosporins are empirically prescribed in the general medicine department. Male patients accounted for (61.3%) and female patients were (38.6%). Majority of study population diagnosed with Urinary tract infection 21.33% (UTI) followed by other disorders like Lower respiratory tract infections 18.66% (LRTI), Upper respiratory tract infections11.33% (URTI) as primary disease. 32% of co morbidity conditions were seen . Majority of cephalosporins were prescribed in injection form (64.6%) and oral form (35.33%). A total of 7 ADR and it has been identified. Among the classification of cephalosporins mostly, Third generation cephalosporins were mostly prescribed (80.65%). Conclusion: Study concludes that out 150 patients ,most patients hospitalized with Urinary tract infection and followed by other disease conditions. Mostly third generations cephalosporins were used to treat in various conditions in general medicine ward. Mostly IV route was prescribed based on the conditions. It shows that the cephalosporins are appropriately prescribed according to the guidelines.