A PROSPECTIVE OBSERVATIONAL STUDY OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED BREAST CANCER IN TERTIARY CENTRE

Abstract

Introduction: Carcinoma of the breast from the very beginning has been a feared disease.' Till today, there is an aura of fear that surrounds the mention of this name 'breast cancer'. Neoadjuvant chemotherapy (NAC) is increasingly used to treat patients with locally advanced breast cancer (LABC). Such regimens can increase rates of breast-conserving therapy (BCT) compared with post-operative chemotherapy 2 and may minimize the need for aggressive nodal surgery with axillary lymph node dissection. To assess Aims: the change of clinical staging after Neoadjuvant Chemotherapy, Assessment of Lymph node status after neoadjuvant Chemotherapy and type of surgery suitable after neoadjuvant Chemotherapy. The present study was a hospital Materials and method: based observational study. The study conducted in Nil Ratan Sircar Medical College & Hospital. The study duration was One year (June 2021 to May 2022). 50 patients were included in this study. In our study, all patients [50 (100.0%)] had Lymph node involvement. We Result: showed that, most of the patients had Stage IIIA [25 (50.0%)]. However, Stage IIIB [15 (32.0%)] followed by Stage IIIC [10 (20.0%)] which was statistically signicant (p=.00168).It was found that, all patients [50 (100.0%)] had Anterior Chemotherapy. Our study showed that, most of the patients had Stage IIB after chemotherapy [22 (44.0%)] and it was statistically not signicant (p< .14706) (z=1.4499). In our study, higher number of patients had Down stage Result [35 (70.0%)] followed by Same Result [15 (30.0%)] but this was statistically signicant (p=.00006) (z=4). We showed that, the mean Tumor size of patients was [7.2880± 1.4822 (cm)] and mean % of size reduction of patients was [58.0000± 15.0509]. we Conclusion: conclude that, the change of clinical staging after Neoadjuvant Chemotherapy, Lymph node status after neoadjuvant Chemotherapy