Abstract
S: PLENARY and PARALLEL SESSIONS 2 of 5 animals showing a complete response out to 60 days). There was no significant change in tumor LPAM concentration with addition of heat. Average proliferation index following ILP with saline, saline + HT, LPAM, or LPAM + HT was 40%, 28%, 27%, and 16% respectively. CONCLUSIONS: Administration of LPAM with increasing amounts of localized heat yielded increasing growth delay and decreased proliferative index. This demonstrates that the application of hyperthermia, rather than the prevention of hypothermia, is the cause for enhanced therapeutic effect in HILE The interaction between HT and melphalan was synergistic. This interaction could not be explained by increased uptake of drug with the addition of heat. These findings underscore the importance of the use of HT in regional chemotherapy.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call