Abstract
We followed 54 patients who underwent curative hepatectomy for metastasis from colorectal carcinoma at the hospital from January 1990 to October 1995, and investigated their outcomes prospectively. The patients divided into three groups as hepatic arterial infusion (HAI) group (n=14) was given intermittent 5-FU at 1000mg/body via the hapatic artery for 4 hours every 2 week for over 6 week; L-5FU group (n=22) was given 2-week course of continuous 5-FU intravenous infusion at 500mg/body for 5 days a week, followed by leucovorin (30mg/body, day 1) injection; and control group (n=18) was given UFT orally. There was no significant difference in the cumulative 5-year survival rate among 3 groups which were 41% in HAI group, 46% in L-5FU group, and 36% in control group. The disease free survival period in HAI group for both of the lung (P=0.048) and multiorgan (P=0.049) was significantly longer than in control group whereas was no significant difference between L-5FU group and control group. The resection rate in HAI group (57%) for residual liver recurrence was highest among 3 groups (L-5FU group; 14%, control group; 30%). These data indicate that, although HAI and L-5FU therapies contribute little to survival period, anticancer activity for the metastasis of the lung and multiorgan as well as for multiple recurrence of the residual liver in HAI therapy can be expected.
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