Abstract
Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature, and the monomer has certain toxicity. Our study tried to modify the PMMA bone cement by doping with various particle weight fractions (5, 10 and 15%) of SCPP particles and polydopamine-coated SCPP particles (D/SCPP) to overcome its clinical application disadvantages. Our study showed that all results of physical properties of samples are in accordance with ISO 5833. The 15% D/SCPP/PMMA composite bone cement had much better biocompatibility compared with pure PMMA bone cement and SCPP/PMMA composite bone cement due to the best cell growth-promoting mineralization deposition on the surface of 15% D/SCPP/PMMA composite bone cements and Sr2+ released from SCPP particles. Our research also revealed that the reaction temperature was found to be reduced with an increase in doped particles after incorporating the particles into composite bone cements. The novel PMMA bone cements modified by D/SCPP particles are promising materials for bone repair.
Highlights
Polymethyl methacrylate (PMMA) bone cement has been used in clinics for its excellent mechanical properties and simple operation procedure
These results indicated that DOPA increased the connection between Strontium-doped calcium polyphosphate (SCPP) particles and PMMA, and improved the interfacial compatibility between these two materials
We could infer that the D/SCPP/PMMA composite bone cements had better mechanical properties than the SCPP/ PMMA composite bone cements
Summary
Polymethyl methacrylate (PMMA) bone cement has been used in clinics for its excellent mechanical properties and simple operation procedure. PMMA bone cement cannot be degraded, lacks biological activity, and cannot form osseous bonding with host bone tissue. After being implanted in vivo, it is poor in integrating with the surrounding bone tissue and not conducive to bone cell adhesion and growth. Calcium polyphosphate (CPP) is a new type of bioceramic for bone repair and has attracted extensive attention in bone repair; both in vitro and in vivo tests have confirmed that CPP can promote bone growth [1,2]. Our previous studies showed that SCPP can significantly promote the growth of osteoblasts, and it had a good stimulatory effect on the secretion of angiogenic growth factors (including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)) by osteoblasts [3,4]. The SCPP containing 8% Sr has the best effect
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