Abstract
Introduction Carcinoma of the prostate gland is the most common visceral malignant tumor that affects men. Conventional acinar adenocarcinoma represents the majority ( 90%) of the tumors derived from the prostate gland. Uncommon variants (5%-10%) of prostatic adenocarcinoma are readily recognizable by their distinctive histologic features and are important because they might signify a worse clinical prognosis. Primary signet ring cell carcinomas (SRCC) of the prostate are extremely rare. As the name implies, the defining characteristic of the variant is the presence of signet ring cells, which are characterized by a crescent-shaped nucleus that is indented, displaced, and compressed against the cell membrane by a large, clear, cytoplasmic vacuole. Fewer than 60 patients with this rare malignancy have been described in the literature. SRCC of the prostate exhibits a median overall survival of 28 months from initial surgery, which implies a worse prognosis compared with standard adenocarcinomas.
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