Abstract
This is a retrospective cohort study included 1021 patients underwent a flexible GnRH antagonist IVF protocol from January 2017 to December 2017 to explore the effect of a premature rise in luteinizing hormone (LH) level on the cumulative live birth rate. All patients included received the first ovarian stimulation and finished a follow-up for 3 years. A premature rise in LH was defined as an LH level >10 IU/L or >50% rise from baseline during ovarian stimulation. The cumulative live birth rate was calculated as the number of women who achieved a live birth divided by the total number of women who had either delivered a baby or had used up all their embryos received from the first stimulated cycle. In the advanced patients (≥37 years), the cumulative live birth rate was reduced in patients with a premature rise of LH (β: 0.20; 95% CI: 0.05–0.88; p=0.03), compared to patients (≥37 years) without the premature LH rise. The incidence of premature LH rise is associated with decreased rates of cumulative live birth rate in patients of advanced age (≥37 years) and aggravated the reduced potential of embryos produced by the advanced age, not the number of embryos.
Highlights
Over the last few years, gonadotropin-releasing hormone (GnRH) antagonists have been widely used for controlled ovarian stimulation (COS) in assisted reproductive technology (ART) [1]
Body mass index (BMI), basal FSH, antral follicle count (AFC), and the duration of infertility were similar when compared between women with and without a premature rise in luteinizing hormone (LH) (Table 1)
While in the patients with advanced age, the number of oocytes retrieved and the quality of the embryos were not reduced in the patients with the premature LH rise. In this retrospective cohort study, we analyzed the potential effect of a premature rise in LH on the cumulative live birth rate of IVF patients who received GnRH antagonist treatment
Summary
Over the last few years, gonadotropin-releasing hormone (GnRH) antagonists have been widely used for controlled ovarian stimulation (COS) in assisted reproductive technology (ART) [1]. GnRH antagonists can inhibit a premature rise of luteinizing hormone (LH) during COS by competitively binding to GnRH receptors after immediate pituitary suppression [5]. It has been reported that some patients still experience a premature rise of LH after treatment with GnRH antagonists [6]. A comparison of the cumulative pregnancy outcome after both fresh and frozen embryo transfers in cycles where a premature rise in LH level has occurred may help us to understand the effect of this premature LH rise on embryos and pregnancy outcome more directly. The aim of the present study was to identify the effect of a premature LH rise on cumulative live birth rate during IVF cycles involving a GnRH antagonist protocol
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call