A Preliminary Study on the Potential Mechanism of Notch Signaling Pathway in the Regulation of Sudden Sensorineural Hearing Loss

Abstract

Sudden sensorineural hearing loss (SSHNL) is a sudden onset of unexplained sensorineural hearing loss. Studies have shown that the number of patients with SSNHL is increasing year by year, and the average age is decreasing, which seriously affects the quality of life of patients. Its pathogenesis is complex and the mechanisms of hearing loss caused by various causes are quite different, but no matter what the cause is, it is ultimately related to the damage and loss of the inner ear structural hair cells (HCs) and their associated spiral ganglion cells (SGCs). Studies have shown that the Notch signaling pathway can regulate the development of the inner ear and nervous system in mammals. Hes family, Math1, DNER, Wnt signaling, and the lateral induction and lateral inhibition of Notch signaling related to the Notch signaling pathway are all key factors for the differentiation and development of HCs and SGCs. Based on the existing research, this paper makes a comprehensive and systematic summary, summarizes the importance of HCs and their afferent partner SGCs in SSNHL, and the relationship between Notch signaling pathway and the existence of the two, to provide a reference for clinical treatment of SSNHL in the future.