A precise electrochemical sensor based on Sm2O3/2D TiC hybrid for highly sensitive and selective detection of antihypertensive drug nimodipine

Abstract

Hybridization of rare earth metal oxide with titanium carbide is a well-designed architecture for uses in sensing, energy conversion and storage, electronic devices, catalysis, and other applications. Herein to synthesized, a Sm2O3/2D TiC hybrid (samarium oxide/two-dimensional titanium carbide) using a facile hydrothermal process. The as-prepared hybrid was examined by various physicochemical techniques such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Field emission scanning electron microscopy (FESEM) and High-resolution transmission electron microscopy (HRTEM). From, the morphology study to confirm the Sm2O3 flakes were successfully hybridized with titanium carbide sheet as a result to enhance the electrochemical active sites, low resistivity, and rapid ion transportation. Due to this behavior the modified Sm2O3/2D TiC/GCE has successfully detected antihypertensive drug nimodipine (NMP) by using CV (cyclic voltammetry), and DPV (differential pulse voltammetry) analysis. The Sm2O3/2D TiC/GCE sensor has demonstrated high sensitivity (1.5 µA µM−1 cm−2), a low LOD (4.2 nM), excellent repeatability, reproducibility, and storage stability. Particularly, Sm2O3/2D TiC/GCE was effectively used to detect NMP in biological samples and to obtain a well-acceptable result. We believe that, this Sm2O3/2D TiC hybrid electrocatalyst can act as a potential electrode material for the electrochemical detection of NMP in clinical biological applications.