Abstract
The aim of this study was to develop a practical route for preparing a fluorine-18 ([ 18F]) labelled ligand ([ 18F] 1) containing [ 18F]fluorobenzene ring by employing the reaction of diphenyliodonium salt with [ 18F]F −. Diphenyliodonium tosylate ( 2) was synthesized from tributylphenylstannyl compound ( 6) with [hydroxy(tosyloxy)iodo]benzene ( 7). Using this method, [ 18F]DAA1106 ([ 18F] 3a), a positron emission tomography ligand for imaging peripheral-type benzodiazepine receptor, was prepared.
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