Abstract
[ 18F]FEAC ([ 18F] 4a) and [ 18F]FEDAC ([ 18F] 4b) were developed as two novel positron emission tomography (PET) ligands for peripheral-type benzodiazepine receptor (PBR). [ 18F] 4a and [ 18F] 4b were synthesized by fluoroethylation of precursors 8a and 8b with [ 18F]FCH 2CH 2Br ([ 18F] 9), respectively. Small-animal PET scan for a neuroinflammatory rat model showed that the two radioligands had high uptakes of radioactivity in the kainic acid-infused striatum, a brain region where PBR density was increased.
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