A potent larvicidal agent against Aedes aegypti mosquito from cardanol.

Derisvaldo R Paiva,Diego P Sangi,Francisco C Biaggio,Naga P Avvari,Maria Rita Marques,Adilson Beatriz,Dênis P De Lima,Isaias Cabrini,Edson A Dos Santos,Eduardo J De Arruda

doi:10.1590/0001-3765201720160615

Abstract

Cardanol is a constituent of Cashew Nut Shell Liquid that presents larvicidal activity against Aedes aegypti. The isolation of cardanol is somewhat troublesome, however, in this work we describe an efficient and inexpensive method to obtain it as a pure material. The compound was used as starting material to make chemical transformation leading to saturated cardanol, epoxides and, halohydrins. These derivatives were tested for toxicity against Aedes aegypti larvae. The results showed that iodohydrins are very promising compounds for making commercial products to combat the vector mosquito larvae presenting a LC50 of 0.0023 ppm after 72 h of exposure.

Highlights

Studies have shown that CNSL present insecticidal activity
Subsequent studies (Guissoni et al 2013) showed that CNSL when extracted by solvent at 40 oC preserves intense insecticidal activity, which is eightfold greater than that reported by Lomonaco
Anacardic acid is described as antimicrobial (Kubo et al 1993, Reddy et al 2012), antitumor, antioxidant, gastro-protective (Hamad and Mubofu 2015), potential anticarcinogenic such as prostate cancer (Schneider et al 2016), besides it is used as starting material for building many other derivatives of pronounced biological activity (Jiang et al 2015)

Summary

Introduction

Studies have shown that CNSL present insecticidal activity. Lomanaco (2009), reported that technical CNSL exhibits smaller insecticidal activity than cold solvent extracted CNSL (in natura) because the presence of anacardic acid in the latter. Subsequent studies (Guissoni et al 2013) showed that CNSL when extracted by solvent at 40 oC preserves intense insecticidal activity, which is eightfold greater than that reported by Lomonaco. It was obtained the products (0.350 g) that proved to be NMR, a mixture of epoxypropyl ether (70%) and halohydrin (30%) when the starting material was cardanol.

Results

Conclusion