Abstract
A ninhydrin positive compound (L2) from commercially available unfermented dry green tea (Thea sinesis) leaves is found to be a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood. Its potency is compared with caffeine, a member of the methylxanthines family. Both caffeine and L2 inhibit thromboxane formation in whole blood in a dose dependent fashion. L2 inhibition when calculated as I 50by a dose response curve is found to be more than 40 fold stronger tan caffeine as an inhibitor of thromboxane formation. A concentration of L2 as low as 50 μM, supresses thromboxane formation (by 84%) whereas a concentration of 5000 u M is necessary to achieve the same inhibiton with caffeine. The potent inhibitory effect of L2 on the TXB 2 production maybe of benefit in the treatment of vascular disease.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
