Abstract
The current massive vaccination brings a Janus- faced problem. There is a need to assess a positive effect but also to anticipate the abnormal immune response. Repeated administration of aluminum containing vaccines represents a possible risk factor for different aberrant reactions including the autoinflammatory syndrome that at this stage can be called enigmatic post-vaccination phenomena. Described case gave rise to the suggestion that vaccination could cause the undesired and unintentional hyper activation of the inflammatory system due to lymph node hyperplasia. Castleman like disease is presented as autoinflammatory syndrome. The dysfunction in the immune/inflammatory response seems to play an etiologic role and leads to a high degree of systemic, sterile inflammation. A temporal relationship between vaccination and the adverse reactions, latency period, can involve weeks and months. Autoinflammatory disease is interesting by severe chronic anemia of inflammation and with decreased levels in serum lipid profile. The extirpation of localized lymphoid tumor in the abdomen was beneficial to the patient and immediately ended-up the inflammatory state and normalized the abnormal laboratory results. Studies addressing this issue are limited.
Highlights
Vaccination has been the most successful medical intervention in history
Syndrome is a classification for chronic inflammation with a distinct therapeutic role for blocking pro-inflammatory cytokines, especially interleukin-1β
A coherence of vaccination and autoimmune/inflammatory syndrome is formulated mainly on the basis of case reports and the causal link is vehemently disputed. These diseases arise in genetically predisposed subjects and require an environmental trigger including vaccination, Wraith et al (2003)
Summary
Vaccination has been the most successful medical intervention in history At present it is in children and adolescents very effective tool to prevent infectious diseases. A coherence of vaccination and autoimmune/inflammatory syndrome is formulated mainly on the basis of case reports and the causal link is vehemently disputed. These diseases arise in genetically predisposed subjects and require an environmental trigger including vaccination, Wraith et al (2003). Its description by positron emission tomography (PET) combined with CT: increased metabolism of glucose in the viable lesion This solitary hypodense, non penetrans tumor was located in the subhepatic space under the left lobe of hepar, size 61x46x39mm. The amount of aluminum in the tumor tissue was 7μg/g, seven fold more than the control
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