Abstract
Manganese as an environmental neurotoxicant can cause oral exposure. Six rats were equipped with a connector “crown”, allowing repeated recording of electrocorticogram (ECoG) with simultaneous recording of motor activity in an open field box. Weekly one 30-min recording session was held, and after two control sessions, four of the six rats had 2.5 mg/ml manganese chloride in their drinking water. The treated rats showed higher motility during the exposure period than the untreated ones; and substantially decreased total ECoG power without marked change the spectrum. The changes of both motility and ECoG were correlated to the individual brain Mn levels, and the activity decrease during a session was correlated to the total ECoG power. These effects can be likened to early adult manganism and to symptoms of children exposed to Mn via drinking water. Repeated simultaneous recording of open field motility and spontaneous cortical activity seems suitable to detect early electrophysiological and behavioral effects of an oral neurotoxic exposure.
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