A pilot study to compare two types of heat-stabilized rice bran in modifying compositions of intestinal microbiota among healthy Chinese adults

Abstract

The purpose of this pilot study is to evaluate the feasibility and acceptability of a rice bran dietary intervention for healthy Chinese adults, and its effects on the participants’ gut microbiome. Sixteen participants were randomized into two groups (Groups A and B), each consuming a different brand of rice bran. The feasibility of the intervention was assessed by the retention rate, and participants’ compliance to the study. Its acceptability was evaluated by participant satisfaction with the study. Changes in the microbiota profile of their stool samples were analyzed through metagenomic sequencing. High retention (81%) and compliance rates (88.0% and 93.8%) were observed. Most agreed the rice bran they consumed was palatable. A decrease in the intestinal abundance of Firmicutes ( P = 0.01), and an increase in that of Bacteroidetes ( P = 0.02), was reported in the stool samples of the participants post-intervention. Interestingly, the fecal abundance of certain propionate producers ( Veillonellaceae ) was increased post-intervention ( P < 0.01), while that of butyrate producers ( Faecalibacterium prausnitzii ) was decreased ( P = 0.01). Our data show that the intervention was feasible and acceptable to the participants, and could result in changes in the composition of intestinal microbiota that maintains intestinal health in Chinese adults.