Abstract
The biological mechanisms leading to chronic antibody-mediated rejection (CAMR), a major cause of late graft failure following kidney transplantation, are still poorly defined. Although anti-donor HLA antibodies are commonly associated with poor graft outcome; less attention had been paid to other players of the adaptive immune system.
Highlights
The biological mechanisms leading to chronic antibodymediated rejection (CAMR), a major cause of late graft failure following kidney transplantation, are still poorly defined
We show that T cell monitoring, and especially CD8 TCR repertoire alterations, may allow identifying patients at risk of graft dysfunction
The Vb repertoire alteration occurs years before the appearance of de novo anti-HLA antibodies. These patients with an altered TCR repertoire exhibit an increase in effector memory CD45RA-CD197CD8+ T cells with an accumulation of differentiated (CD28low) CD8 T cells
Summary
A phenotypic, transcriptional and TCR Vb repertoire signature of CD8+ T cells define a population at-risk of long-term kidney graft dysfunction. Nicolas Degauque1,2,3*, Françoise Boeffard, Annaick Pallier, Richard Danger, Magali Giral, Jacques Dantal, Yohann Foucher, Cécile Guillot-Gueguen, Jean-Paul Soulillou, Sophie Brouard. From 7th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk aan Zee, the Netherlands. From 7th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk aan Zee, the Netherlands. 28-30 November 2012
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