Abstract
Silver sulfadiazine 1% cream (SSD) has been the gold standard for treatment of partial thickness and mid-dermal burns. However, SSD has several disadvantages including at least daily dressing changes and significant pain with removal of the SSD prior to re-application. Previously in a Phase II trial, a Hydrofiber® moisture-retention dressing combined with 1.2% ionic silver (AQUACEL® Ag - AQAg) was studied in the treatment of partial thickness burns. AQAg had satisfactory rates of reepithelialization, reduction in pain during dressing changes, and sustained antimicrobial activity. A Phase III, prospective, randomized, multi-center study, involving 8 United States burn centers, compared AQAg versus SSD, for up to 21 days, as wound dressing in the treatment of partial thickness and mid-dermal burns. Patients were at least 2 months of age, sustained mainly a flash, flame, or scald burn which involved between 5–40% total body surface area (TBSA), and had not been treated with antibiotics...
Published Version
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