Abstract
The LD50 (intraperitoneal) of dl-desoxyephedrine hydrochloride for rats and mice was determined to be 54.48 and 61.16 mg./Kg., respectively. The oral LD50 for mice was 143 mg./Kg. Chronic toxicity data following intraperitoneal injections in rats are reported. Effects of the drug on the isolated uteri and on the isolated ileum of both mice and guinea pigs were determined. The drug counteracted both pilocarpine and barium spasm of the intestine of these animals. Body temperature was elevated by small doses of dl-desoxyephedrine. The compound usually stimulated respiration and caused hypotension in anesthetized rabbits. In dogs the pressor effect was only about 1/500 that of epinephrine.
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