Abstract
A method has been developed for isolating and purifying a macromolecular water-soluble component from human hepatic bile by precipitation from barbital solution. The purity and homogeneity of the component have been demonstrated by paper electrophoresis, ultracentrifugation and electron microscopy. The component is a mucoprotein composed of nearly spherical macromolecules 150 Å in diameter with an extrapolated sedimentation constant in water of 22.6 S. The presence of the mucoprotein in human bile may be correlated with the occurrence of cholecystitis and biliary calculi.
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