Abstract
Fatty acid primary amides are potent, bioactive molecules. Oleamide induces physiological sleep1,2, potentiates the action of 5-hydroxytryptamine on rat brain 5-HT2A and 5-HT2C receptors3, and blocks gap junction communication in glial cells4. Erucamide stimulates angiogenesis5, arachidonamide is a tight-binding inhibitor of human synovial phospholipase A2 6, and valpromide (n-propylpentanamide) is used clinically as an antiepileptic7. These studies indicate that the fatty acid primary amides are an exciting new class of mammalian, bioactive lipid. The biosynthetic pathway leading to the formation of the fatty acid primary amides is not understood and is information critical to the understanding and control of diseases related to their production.
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