Abstract
Different biophysical techniques were used to study uromodulin isoforms using experimental models of urine formation (ionic composition, osmolality, pH) in the presence of intact uromodulin and its isoforms isolated from patients with urolithiasis. A model of a medical screening device for persons with preclinical urolithiasis was tested. The concept of targeted therapy of urolithiasis based on the modulation of the properties of uromodulin was put forth.
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