Abstract
The aim of this study was to design a panel of gene polymorphism detection of MAFLD in East Asian population based on current research. Literature search was conducted in PubMed database using the keywords "metabolism-related fatty liver" or "non-alcoholic fatty liver" and "Asia" or "East Asia" and "gene”. 41 studies met the inclusion criteria, and 12 key genetic loci were screened out involving FTO, KLB, PNPLA3, TRIB1, PPARα, LEPR, APOA5, TM6SF2, APOC3, GCKR, SREBP2, MTTP, associating with obesity, insulin resistance, glucose metabolism, fatty acid metabolism, and inflammatory fibrosis pathways. The panel was designed successfully, while the sensitivity and specificity remain to be further clinically validated.
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