Abstract
A pair of new sesquiterpene isomers containing a spiro heterocyclic skeleton, dothimes A ( 1 ) and B ( 2 ), together with six known compounds, quindoline ( 3 ), ( S )-3-(3-indolyl)lactic acid methyl ester ( 4 ), dankasterone B ( 5 ), dibutyl phthalate ( 6 ), (1 S ,3 R ,4 R ,7 S )-3,4-dihydroxy- α -bisabolol ( 7 ), and p -hydroxybenzaldehyde ( 8 ), were isolated from the plant-derived fungus Botryosphaeria dothidea . The structures of all isolated compounds were determined based on extensive spectroscopic analyses, including 1D/2D nuclear magnetic resonance (NMR), and high resolution electrospray ionization mass spectrometry (HRESIMS) data, as well as by comparison with literature reports. Compounds 1 and 2 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC 50 values of 63.66 and 58.29 μM, respectively. • A pair of new sesquiterpene isomers was isolated from Botryosphaeria dothidea . • The structures of 1 and 2 were elucidated by spectroscopic analyses. • Compounds 1 and 2 showed weak anti-inflammatory activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
