Abstract
NMR was used to study the binding of Na in the saliva of patients with cystic fibrosis of the pancreas (CFP). The purpose of this investigation was to determine whether Na binding can account for the inhibition of Na transport in the duct of the salivary gland which prevents Na reabsorption and results in much higher than normal concentrations of Na in the saliva of CFP patients. It was found that most of the Na in the saliva of CFP patients is not exchanging slowly onto a macromolecule. The same results were found for controls. Therefore, Na binding cannot account for the high concentrations of Na found in the saliva of CFP patients.
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