Abstract
The aim of this study is to prove the antifungal and antibacterial activity of Ginko Biloba GKB from glycerin nanocapsules and nanoemulsions. GKB was formulated as spray formulation for topical application using ethyl alcohol 95%/glycerol/water based formulations. GKB spray was evaluated for their particle size distribution, pH, content uniformity, content per spray, in vitro release and antifungal activity. The antifungal activity determined by Agar well-diffusion method. The formulae were tested for their skin permeation and the stability of the formulations. The results showed uniform formulae with nano-sized particles, pH compatible with the topical formulation and higher drug content. Diffusion studies of the optimized formulations through the abdominal rabbit skin showed higher penetrated drug over a period of 24 h. Stability studies indicated that formulations were stable. Skin irritation studies confirmed the compatibility of spray formulae with skin. Agar well-diffusion method showed that GKB was effective compared with fluconazole. The inhibition zones for all formulae were significant as compared with standard fluconazole. The results obtained showed that the topical spray formulation could be a promising and innovative therapeutic system as topical antifungal for the transdermal administration of GKB. The developed formulation can be used for delivery from spray formulation. This study proved the local activity of GKB as antifungal drugs.
Highlights
Several different antifungal preparations were used to treat various fungal infections [1,2]
The duration of treatment depends on kind of fungal infection, health problems of the infected patient, problems associated with immune system and types of formulations
The antifungal activity was determined by Agar welldiffusion method
Summary
Several different antifungal preparations were used to treat various fungal infections [1,2]. They are formulated as sprays, creams, solutions, ointment, shampoos, vaginal tablets, oral medicines, and injections [3]. Antifungal liquids or sprays (topical antifungals) can be used to treat skin fungal infections, scalp and nails [5]. These antifungal drugs can cause various type of adverse effect such as burning or redness at the site of application [6,7]. GKB has antifungal activity against some kind of endophytic. GKB extract holds flavonoid glycosides and unique terpene lactones as main active constituents [9]
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