Abstract
A novel method consisting four-step from tert-butyl acrylate ( 4) and chloromethyl phenyl sulfoxide ( 5) for preparing cis-2-fluorocyclopropane-1-carboxylic acid ( cis- 3 ) was elaborated. The method involves initial formation of the cis-2-phenylsulfinylcyclopropanecarboxylate ( cis- 6 ), fluorination by molecular fluorine to trans- 7 , reductive desulfonylation to the ester ( cis- 9 ) and acid-catalyzed hydrolysis to the final product ( cis- 3 ).
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