Abstract
Background: Animal models of absence epilepsy are widely used in childhood absence epilepsy studies. Absence seizures appear in the brain’s electrical activity as a specific spike wave discharge (SWD) pattern. Reviewing long-term brain electrical activity is time-consuming and automatic methods are necessary. On the other hand, nonlinear techniques such as phase space are effective in brain electrical activity analysis. In this study, we present a novel SWD-detection framework based on the geometrical characteristics of the phase space. Methods: The method consists of the following steps: (1) Rat stereotaxic surgery and cortical electrode implantation, (2) Long-term brain electrical activity recording, (3) Phase space reconstruction, (4) Extracting geometrical features such as volume, occupied space, and curvature of brain signal trajectories, and (5) Detecting SDWs based on the thresholding method. We evaluated the approach with the accuracy of the SWDs detection method. Results: It has been demonstrated that the features change significantly in transition from a normal state to epileptic seizures. The proposed approach detected SWDs with 98% accuracy. Conclusion: The result supports that nonlinear approaches can identify the dynamics of brain electrical activity signals.
Highlights
Epilepsy is one of the most common neurological disorders, afflicting 1% of the population
We evaluated the approach with the accuracy of the spike-wave discharges (SWDs) detection method
The result supports that nonlinear approaches can identify the dynamics of brain electrical activity signals
Summary
Epilepsy is one of the most common neurological disorders, afflicting 1% of the population. Patients with epilepsy suffer from social problems and momentary lapses of consciousness. Absence seizures are general seizures, which highly occur in children between 4-12 years old and adolescents with juvenile absence epilepsy. The absence seizures appear in electroencephalogram (EEG) signals with particular spike-wave discharges (SWDs) with a frequency of about 3 Hz and a short duration (5-30 seconds).[1,2]. Animal models of absence epilepsy are widely used in childhood absence epilepsy studies. Absence seizures appear in the brain’s electrical activity as a specific spike wave discharge (SWD) pattern. Reviewing long-term brain electrical activity is time-consuming and automatic methods are necessary. We present a novel SWD-detection framework based 2296787, Email: a.younessi7@
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