Abstract
Using nanopore for DNA unzipping has been extensively studied. By measuring the voltage-dependent duration of current blocks produced by the unzipping process, one can evaluate the force and energy involved in the double strands hybridization. However, in the real-time biosensing, other molecules co-existing in the mixture may also produce blocks in similar amplitude and duration. Therefore a characteristic current signature is needed to discriminate the unzipping signal from other blockades. Here we identify a novel molecular signature that can reveal sequential steps in DNA unzipping in the nanopore.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
