A novel simulador for agile and graphical modeling of surface plasmon resonance based sensors

Abstract

Surface plasmon resonance (SPR) sensor is a consolidated technology for analysis of biomolecular interaction, largely applied in biology and pharmaceutical research. The simulation of the surface plasmon optical excitation response is an important step in the development process of SPR based sensors. The structure, design and configuration of the desired sensor benefits from a previous simulated analyses of the generated responses, defining operational conditions and feasibility of the selected materials to composed the optical coupling layers. Here an online web-based SPR sensor’s simulator is presented. With a visual-oriented interface, enable drag & drop actions to easily and quickly model a variety of sensor arrangements. Presenting an embedded materials database for metals, glasses, 2D materials, nanoparticles, polymers, and custom substances, the simulator enables flexible configuration for sensors operating in angular and spectral modes, as well as localized SPR. The light propagation through the multilayer of materials is presented in terms of Fresnel coefficients, which are graphically displayed. The so-called SPR morphology parameters can be visualized. Moreover, sensor dynamic behavior could be knowledge by a Sensorgram simulation. Localized surface plasmon resonance (LSPR) in homogeneous and spherical nanoparticles is also present in the simulator. Simulated scenario’s in various configurations, designs and excitation were performed and compare with other simulator. The proposed simulator guarantees comparable results with low-code, agile, and intuitive flow of execution.