Abstract
From active developments and applications of various devices to acquire outside and inside information and to operate based on feedback from that information, the sensor market is growing rapidly. In accordance to this trend, the surface plasmon resonance (SPR) sensor, an optical sensor, has been actively developed for high-sensitivity real-time detection. In this study, the fundamentals of SPR sensors and recent approaches for enhancing sensing performance are reported. In the section on the fundamentals of SPR sensors, a brief description of surface plasmon phenomena, SPR, SPR-based sensing applications, and several configuration types of SPR sensors are introduced. In addition, advanced nanotechnology- and nanofabrication-based techniques for improving the sensing performance of SPR sensors are proposed: (1) localized SPR (LSPR) using nanostructures or nanoparticles; (2) long-range SPR (LRSPR); and (3) double-metal-layer SPR sensors for additional performance improvements. Consequently, a high-sensitivity, high-biocompatibility SPR sensor method is suggested. Moreover, we briefly describe issues (miniaturization and communication technology integration) for future SPR sensors.
Highlights
A sensor is defined as any device that converts one or more types of information, such as pressure, velocity, acceleration, temperature, frequency, and biological signals, into readable quantitative signals [1,2,3]
The authors described several factors that contribute to sensitivity enhancement by employing gold nanoparticles in that research: (1) the particular binding event increases the mass on the surface compared with a bare target molecule; (2) the refractive index of the gold particle is much higher than that of the biomolecules; (3) the surface plasmon resonance (SPR) response may increase via electromagnetic coupling between the metallic nanoparticles and the film by influencing the plasmonic mode propagation [94]
Several advanced SPR sensors based on nanotechnology were introduced: (1)
Summary
A sensor is defined as any device that converts one or more types of information, such as pressure, velocity, acceleration, temperature, frequency, and biological signals, into readable quantitative signals [1,2,3]. From active developments and applications of various devices to acquire inside and outside information and to operate based on feedback from that information, the sensor market is rapidly growing. The surface plasmon resonance (SPR) sensor has been developed for high-sensitivity real-time detection [14,15,16,17,18,19]. In the section on the fundamentals of SPR sensors, a brief description of surface plasmon resonance (SPR) phenomena, SPR-based sensing applications, and several configuration types of SPR sensors are introduced. We suggest a performance-enhanced LSPR sensor method integrated with a double-metal-complex nanostructure to enhance the sensitivity and biocompatibility in a practical way without biofunctionalization. A brief prospect of how SPR sensors can be integrated with technologies during the current phase of the 4th industrial revolution is suggested in the concluding remarks
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