Abstract
Background and Aims: The pathogenic mechanisms underlying development of nonalcoholic steatohepatitis are still elusive. Indoleamine 2,3-dioxygenase (IDO-1), an enzyme that mediates the catabolism of L-tryptophan to L-kynurenine, plays an important role in hepatic immune regulation, mediating inflammation or tolerance depending on the type of injury and the tissue involved. In the present study, we examined the effect of pharmacological or genetic inhibition of IDO-1 on the development of steatohepatitis induced by a methionine and choline-deficient (MCD) diet in mice.
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