Abstract
Renin-secreting cells are critical for survival. These cells control blood pressure (BP), fluid-electrolyte homeostasis, tissue perfusion, kidney development, and repair of damaged glomeruli 1 Sequeira-Lopez M.L.S. Gomez R.A. Renin cells, the kidney, and hypertension. Circulation Research. 2021; 128: 887-907 Crossref PubMed Scopus (12) Google Scholar . Renin-secreting cells descend from mesodermal-derived precursors that differentiate into the mural cells of the kidney arterial tree 1 Sequeira-Lopez M.L.S. Gomez R.A. Renin cells, the kidney, and hypertension. Circulation Research. 2021; 128: 887-907 Crossref PubMed Scopus (12) Google Scholar . Mature renin-secreting cells are confined to the tips of the renal arterioles near the glomeruli, thus their name juxtaglomerular (JG) cells 1 Sequeira-Lopez M.L.S. Gomez R.A. Renin cells, the kidney, and hypertension. Circulation Research. 2021; 128: 887-907 Crossref PubMed Scopus (12) Google Scholar (Figure 1a). Other renin-lineage cells along the afferent arterioles can re-express renin in response to decreased kidney perfusion or fluid losses, resulting in an increased number of renin-secreting cells to restore homeostasis 1 Sequeira-Lopez M.L.S. Gomez R.A. Renin cells, the kidney, and hypertension. Circulation Research. 2021; 128: 887-907 Crossref PubMed Scopus (12) Google Scholar . Understanding how these cells differentiate and regulate renin expression and release may improve the management of hypertension and cardiovascular and kidney diseases. In a recent article published in the Journal of Clinical Investigation, Gunawardhana and colleagues present a novel approach to study the underlying mechanisms of hypertension and hypothesize a possible role for the vascular smooth muscle cell gene Prdm6 in determining the abundance of renin-secreting cells. 2 Gunawardhana K.L. Hong L. Rugira T. Uebbing S. Kucharczak J. Mehta S. Karunamuni D.R. Cabera-Mendoza B. Gandotra N. Scharfe C. Polimanti R. Noonan J.P. Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. The Journal of Clinical Investigation. 2023; : 133 Google Scholar
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