Abstract

1, 3-Disubstituted 5-acylamino-6-methyluracils ( 2a-e) were transformed into 1, 2-disubstituted 4-alkylcarbamoyl-5-methyl-1 H -imidazoles ( 3a-e) by treatment with 5% aqueous sodium hydroxide in ethanol. Similarly, reaction of 5-acylamino-6-methyl-3-phenyl-4-(3 H )-pyrimidinones ( 5a-d) with 5% aqueous sodium hydroxide in ethanol gave 2-substituted 5-methyl-4-phenylcarbamoyl-1 H -imidazoles ( 6a-d).

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