Abstract
Calcium flux assay is widely used for monitoring GPCRs and calcium channels. However, most common calcium indicators (such as Fluo-3 and Fluo-4) have green fluorescence, making them impossible to be used with GFP cells or multiplexed with another green fluorescent dye. Although the rhodamine-based calcium indicators (such as Rhod-2 AM) could help alleviate this limitation, the undesired mitochondrial localization makes it much less sensitive. Cal-590 AM, a new long wavelength calcium indicator, has been developed for monitoring calcium with red fluorescence (Ex/Em= 570/590 nm).
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