Abstract
Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase Cδ in Dopaminergic Neuronal Cells
Highlights
Oxidative stress and apoptosis are key mediators of numerous neurodegenerative processes in the nervous system, including Alzheimer (4, 5) and Huntington disease (6, 7), Friedrich
We demonstrated that protein kinase C-␦ (PKC␦) is an oxidative stress-sensitive kinase that can be activated by caspase-3-dependent proteolytic cleavage to induce apoptotic cell death in cell culture models of Parkinson disease
To determine whether oxidative stress induces the proteolytic activation of PKC␦ in dopaminergic neuronal cells, we examined the effect of H2O2 on PKC␦ cleavage in N27 cells
Summary
Oxidative stress and apoptosis are key mediators of numerous neurodegenerative processes in the nervous system, including Alzheimer (4, 5) and Huntington disease (6, 7), Friedrich. We demonstrated that protein kinase C-␦ (PKC␦) is an oxidative stress-sensitive kinase that can be activated by caspase-3-dependent proteolytic cleavage to induce apoptotic cell death in cell culture models of Parkinson disease
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
