Abstract
β-1,3-glucans such as schizophyllan (SPG) and curdlan can form a novel complex with polynucleotides through hydrogen bonding between the two main chain glucoses and the one nucleotide base. The complex can be used as carriers for therapeutically functional polynucleotides such as antisense DNA, siRNA and CpG ODN. Cellular uptake efficiency of the complexes was remarkably enhanced by attaching functional groups that can be recognized by cells. Recent immunology revealed that a receptor dectin-1, normally expressed on antigen presenting cells (APCs) such as macrophages and dendritic cells, can recognize β-1,3-glucans. This fact suggests that the complex can deliver the bound DNA to the APCs. The present article reviews the fundamental and structural studies of this novel complex as well as a recent result for applying its complex to DNA carriers.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
