Abstract
The safe and effective polyrotaxane-based drug delivery system could potentially increase the antiproliferative activity of antitumor medicine. A novel scutellarin–polyrotaxane (SCU–PR), in which scutellarin (SCU) was covalently bound to one of the hydroxyl groups of polyrotaxane (PR), was synthesized, and its characterization was further investigated by NMR, XRD, TG, DSC. The cytotoxicity of SCU–PR was assessed in vitro using human HCT116 and LOVO cell lines in results that the IC50 values of SCU–PR (1.03×10−6 and 1.01×10−6mol/L, respectively), which compared with those of free SCU (7.80×10−5 and 7.70×10−5mol/L, respectively), were lower. The valuable properties of SCU–PR will be potentially useful for its application on human colon cancer chemotherapies.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
