A novel paradodecatungstate-B compound decorated by transition metal copper, Na2Cu5(H2O)24(OH)2[H2W12O42]·10H2O: Synthesis, structure and antitumor activities

Abstract

A new paradodecatungstate-B compound decorated by transition metal copper, Na2Cu5(H2O)24(OH)2[H2W12O42]·10H2O (1), has been synthesized by convenient aqueous solution method and structurally characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis and TGA. The compound crystallizes in the triclinic P-1 space group with a=10.7140(8) Å, b=12.9476(9) Å, c=13.6696(10) Å, α=73.56°, β=75.73°, γ=67.69°, V=1661.8(2) Å3 and Z=1. In compound 1, polyanion of [H2W12O42]10− acts as a dodecadentate ligand that links copper and sodium cations, forming a remarkable three-dimensional framework. The experiment of antitumor activities in vitro shows that the title compound exhibits remarkable inhibitory actions on human cervical carcinoma HeLa cells, ovarian carcinoma SKOV-3 cells, hepatoma HepG2 cells and neuroblastoma SHY5Y cells.