Abstract
In eukaryotes, lipid droplets (LDs) composed of phospholipid monolayers and neutral lipids are crucial spherical subcellular organelles with diameters ranging from 40 nm to 100 μm. LDs play a pivotal role in various physiological activities and are closely associated with many diseases. Therefore, it is essential to develop a fluorescent probe with excellent photostability and large Stokes shift (∼100 nm) for tracking LDs. Herein, a novel lipid droplet-specific fluorescent bioprobe based on coumarin-substituted p-nitrophenyl ethylene was designed and constructed, which exhibited the desirable effects of excellent photostability, favorable resistance to ionic interference, low cytotoxicity and LDs specificity. As a proof of principle, we labeled and imaged LDs of HeLa cells by Cou-LDs successfully.
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