Abstract
Lipid droplets (LDs) and lysosomes serve as important subcellular organelles, which plays an important role in a variety of physiological processes. The components in lipid droplets can be degraded by lysosomes, so it is of great value to study the relationship between LDs and lysosomes. However, few polymer fluorescent probes targeting both lipid droplets and lysosomes have been reported. Therefore, we developed a novel polyethylene glycol fluorescent probe PEG-Nap-Lyso that could be applied to simultaneously track lysosomes and lipid droplets. PEG-Nap-Lyso was able to not only track cells in different physiological environments, but also differentiate live cells from dead cells by changes in the polarity of the intracellular microenvironment. In addition, the probe showed the advantages of amphiphilicity, pH resistance, high selectivity, good stability (3600 s), low biotoxicity and large Stokes shift (167 nm). These excellent properties made the fluorescent probe PEG-Nap-Lyso provided an effective way to study the relationship between LDs and lysosomes.
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