A novel ion selective PVC membrane electrode for determination of propranolol in pharmaceutical formulation

Abstract

A novel ion selective PVC membrane electrode for determination of propranolol is developed. Silicotungstic acid is used as the counter ion and diisononyl phthalate (DNP) used as the plastizer. The electrode exhibits excellent potential respon se properties, showing a Nernstian response in the concentration of 3.0 〈 10-6~ 2.6 〈 10-2 M with the slope of 54.7 mV per decade, shorter conditioning time (~ 3 h), fast response time (40 s), a lower limit of detection (1.0 〈 10-7 M). The electrode is success- fully used for the analysis of propranolol in pharmaceutical formulation with the recoveries of 99.2 ~ 102.6 %, by using a direct potentiometric method and which does not require tedious sample preparation.